top of page

Histamine Support Supplement

Histamine Support Supplement

This video is about a fantastic supplement called D-Hist that has been of great benefit for me and many of my patients.

Orthomolecular, which is available through practitioners and conveniently accessible through Fullscript, is a high quality supplement that I have found easy to digest. I found Orthomolecular through this D-Hist product. This supplement is formulated to provide comprehensive support for seasonal allergies, although I have found it to be useful for managing histamine-related issues beyond just seasonal challenges. It's designed to stabilize mast cells, reduce histamine levels, and maintain a normal inflammatory balance in the body.

D Hist is named for the DAO enzyme which is crucial for breaking down histamine, a chemical compound found in many foods, and which is released in response to the body’s allergic reaction to things like grasses and pollens. Some individuals have low levels of DAO, leading to histamine intolerance and a range of unpleasant symptoms. Common symptoms of histamine intolerance include headaches, nasal congestion, hives, itching, digestive issues, and fatigue.

Causes of Low DAO Levels

Several factors can contribute to low levels of DAO in the body. Here are some common causes:

  1. Genetics: Some individuals may have a genetic predisposition to lower DAO levels or impaired DAO function. Genetic variations can affect the production, activity, or regulation of DAO enzymes.

  2. Poor diet: Certain dietary factors can interfere with DAO production or increase histamine levels in the body. Consuming a diet high in histamine-rich foods or foods that trigger histamine release can overwhelm the body's ability to break down histamine effectively.

  3. Gut issues: Intestinal health plays a crucial role in DAO production and function. Conditions that affect the gut, such as leaky gut syndrome, small intestinal bacterial overgrowth (SIBO), or inflammatory bowel disease (IBD), can disrupt DAO production and lead to lower levels.

  4. Medications: Some medications can inhibit DAO activity or interfere with histamine metabolism. Nonsteroidal anti-inflammatory drugs (NSAIDs), antihistamines, antidepressants, and certain antibiotics are known to affect DAO levels or function.

  5. Hormonal changes: Fluctuations in hormone levels, particularly estrogen, can influence DAO activity. Estrogen has been shown to increase histamine production and reduce DAO activity, which may contribute to histamine intolerance.

  6. Enzyme deficiency: In rare cases, individuals may have a deficiency in the enzymes responsible for producing or activating DAO, leading to lower levels.

Managing Histamine Intolerance

Managing histamine intolerance involves adopting strategies to reduce histamine levels in the body and minimize exposure to histamine-rich foods and other triggers. Here are some tips for managing histamine intolerance:

  1. Follow a low-histamine diet: Identify and avoid or limit foods high in histamine, such as fermented foods, aged cheeses, processed meats, shellfish, certain fruits (e.g., citrus, strawberries), and certain vegetables (e.g., tomatoes, spinach). Be aware that histamine levels can vary in foods, so it's essential to pay attention to individual tolerance and reactions. You can find a list here:

  2. Avoid histamine-releasing foods: Some foods may trigger the release of histamine in the body, even if they are not inherently high in histamine. Examples include alcohol, bananas, chocolate, nuts, and certain food additives. Keeping a food diary can help identify personal triggers.

  3. Support gut health: A healthy gut is crucial for proper histamine metabolism. Focus on maintaining a balanced and diverse diet, including fiber-rich foods, probiotics, and prebiotics. Consider addressing any underlying gut issues with the help of a healthcare professional.

  4. Manage stress: Stress can worsen histamine intolerance symptoms. Incorporate stress-reduction techniques into your routine, such as meditation, deep breathing exercises, and of course acupuncture!

Menopause and perimenopause can have an impact on histamine levels in the body, potentially leading to an increase in histamine-related symptoms.

In perimenopause, estrogen levels can rise. Estrogen stimulates mast cells to make more histamine.

This can cause a dangerous cycle when estrogen causes mast cells to release histamine and the rising histamine levels produce more estrogen. Then the estrogen triggers the mast cells to make more histamine, creating a potentially uncomfortable cycle.

D-Hist is a supplement designed to provide comprehensive support for seasonal challenges caused by common environmental allergens. It is formulated with a combination of flavonoids, antioxidants, proteolytic enzymes, and botanicals known for their potential benefits in promoting a healthy response to allergens. the key ingredients and their roles are:

  1. Quercetin: Quercetin is a biologically active flavonoid antioxidant found in various plants, including onions, oak trees, and tea. It has antioxidant and anti-inflammatory properties and is known for its ability to stabilize mast cells, which helps reduce the release of histamine. By diminishing histamine release, quercetin may support a balanced immune response during seasonal changes.

  2. Stinging Nettles Leaf: Stinging nettles (Urtica dioica) is a plant that has been traditionally used for its potential benefits in balancing immune response, particularly in the airways and nasal passages. It may help control mast-cell degranulation, prostaglandin formation, and histamine action, thereby promoting a more balanced inflammatory response.

  3. Bromelain: Bromelain is a proteolytic enzyme naturally found in pineapple stems and fruit. It has been shown to aid in the breakdown of large protein complexes, including antigenic compounds associated with hypersensitivity reactions. Bromelain may enhance the absorption of quercetin and has been suggested to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort.

  4. N-Acetyl Cysteine (NAC): NAC is an amino acid precursor to glutathione, one of the most important antioxidants in the body. It has mucolytic properties, meaning it helps reduce the viscosity of mucus and supports the clearing of airways. By promoting respiratory health and supporting antioxidant activity, NAC may contribute to a more comfortable response to environmental allergens.

  5. Vitamin C: Vitamin C is an essential nutrient that supports the immune system and acts as a potent antioxidant. It is known for its diverse health-promoting properties. In the context of environmental allergies, vitamin C may help deactivate histamine and modulate immune response, potentially providing relief from seasonal challenges.

D-Hist is specifically formulated to promote healthy nasal and sinus passages for individuals with elevated histamine and respiratory irritation. By combining these ingredients, D-Hist aims to support a more balanced response to environmental allergens and alleviate discomfort associated with seasonal challenges.

Fullscript is an online catalog that grants you access to supplements and herbs that are usually available only to practitioners. I have set up my account in a way that allows you to order anything through my catalog, and I even have some protocol recommendations that you can find in the FS account.

I hope this video provides you with valuable insights into histamine intolerance, the importance of DAO, and how supplements like D-Hist can help manage histamine-related issues.

Thanks for watching!

Send any questions to


Recent Posts

See All


bottom of page